Interleukin 21 promotes IgG1<sup>+</sup> plasma cell differentiation instead of class switching to IgE via Blimp1 expression.

Hashiguchi, Masaaki; Asatsuma-Okumura, Tomoko; Iwai, Yoshiko

Interleukin 21 promotes IgG1⁺ plasma cell differentiation instead of class switching to IgE via Blimp1 expression.

Hashiguchi, Masaaki; Asatsuma-Okumura, Tomoko; Iwai, Yoshiko.

Afiliação

Hashiguchi M; Department of Cell Biology, Institute for Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Asatsuma-Okumura T; Department of Cell Biology, Institute for Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
Iwai Y; Department of Cell Biology, Institute for Advanced Medical Sciences, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

Eur J Immunol ; : e2451041, 2024 May 25.

Article em En | MEDLINE | ID: mdl-38794862

ABSTRACT

ABSTRACT

IgE is induced by the presence of IL-4 by class switching from IgM through IgG1 to IgE. IL-21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.

Palavras-chave

Class switch; IL21; IgE; IgG1; Plasma cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Eur J Immunol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

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