Your browser doesn't support javascript.
loading
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses.
Cervantes Rincón, Tomás; Kapoor, Tania; Keeffe, Jennifer R; Simonelli, Luca; Hoffmann, Hans-Heinrich; Agudelo, Marianna; Jurado, Andrea; Peace, Avery; Lee, Yu E; Gazumyan, Anna; Guidetti, Francesca; Cantergiani, Jasmine; Cena, Benedetta; Bianchini, Filippo; Tamagnini, Elia; Moro, Simone G; Svoboda, Pavel; Costa, Federico; Reis, Mitermayer G; Ko, Albert I; Fallon, Brian A; Avila-Rios, Santiago; Reyes-Téran, Gustavo; Rice, Charles M; Nussenzweig, Michel C; Bjorkman, Pamela J; Ruzek, Daniel; Varani, Luca; MacDonald, Margaret R; Robbiani, Davide F.
Afiliação
  • Cervantes Rincón T; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Kapoor T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Simonelli L; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Agudelo M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Jurado A; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Peace A; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Lee YE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Guidetti F; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Cantergiani J; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Cena B; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Bianchini F; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Tamagnini E; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Moro SG; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • Svoboda P; Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Pharmacology and Pharmacy,
  • Costa F; Institute of Collective Health, Federal University of Bahia, Salvador, BA 40025, Brazil; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, BA 40296, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06511, USA.
  • Reis MG; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, BA 40296, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06511, USA; Faculty of Medicine of Bahia, Federal University of Bahia, Salvador 40025, Brazil.
  • Ko AI; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Ministry of Health, Salvador, BA 40296, Brazil; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06511, USA.
  • Fallon BA; Department of Psychiatry, Columbia University, and New York State Psychiatric Institute, New York, NY 10027, USA.
  • Avila-Rios S; National Institute of Respiratory Diseases, Mexico City, CP 14080, Mexico.
  • Reyes-Téran G; National Institute of Respiratory Diseases, Mexico City, CP 14080, Mexico; Coordination of the National Institutes of Health and High Specialty Hospitals, Ministry of Health, Mexico City, CP 14610, Mexico.
  • Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
  • Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
  • Ruzek D; Veterinary Research Institute, Brno, Czech Republic; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic; Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
  • Varani L; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland.
  • MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: macdonm@rockefeller.edu.
  • Robbiani DF; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland. Electronic address: drobbiani@irb.usi.ch.
Cell Rep ; 43(6): 114298, 2024 Jun 25.
Article em En | MEDLINE | ID: mdl-38819991
ABSTRACT
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquito-borne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Brasil / Mexico Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes Limite: Animals / Female / Humans / Male País/Região como assunto: America do sul / Brasil / Mexico Idioma: En Revista: Cell Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Suíça