N-glycan signatures identified in the serum from biliary tract cancer patients: Association with clinical diagnosis and prognosis.
J Hepatobiliary Pancreat Sci
; 31(8): 537-548, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38824438
ABSTRACT
BACKGROUND:
Changes in the expression of genes related to glycosyltransferases may lead to alterations in N-glycan structure abundance, potentially acting as markers for diagnosis and prognosis in biliary tract cancer (BTC).METHODS:
This study was divided into cross-sectional and longitudinal approaches. The cross-sectional study included 316 BTC and 301 non-BTC. Propensity score matching was applied to adjust for sex and age differences between BTC and non-BTC. Univariate and multivariate logistic regression identified independent risk factors for BTC and constructed the BTC-G model. The ROC curve was used to validate the diagnostic performance of BTC-G. Longitudinal follow-up studies included postoperative (N = 50) and immunotherapy (N = 43) follow-up cohorts. Cox regression analysis identified N-glycan structures impacting BTC prognosis postoperative and immunotherapy, with further confirmation through Kaplan-Meier curves.RESULTS:
Univariate and multivariate analyses identified Peak3 (OR 0.790, 95% CI 0.658-0.949), Peak9 (OR 1.646, 95% CI 1.409-1.922), and Peak9p (OR 2.467, 95% CI 1.267-4.804) as independent BTC risk factors, leading to the creation of the BTC-G. The ROC curve confirmed that BTC-G performed well in training (AUC 0.753, 95% CI 0.703-0.799), validation (AUC 0.811, 95% CI 0.740-0.870), and CA19-9 negative cohorts (AUC 0.717, 95% CI 0.664-0.767). Cox regression analysis and Kaplan-Meier curves established that Peak12 (HR 5.578, 95% CI 1.145-27.170) and Peak11 (HR 1.104, 95% CI 0.611-1.994) are independent risk factors for BTC prognosis following surgery and immunotherapy, respectively.CONCLUSIONS:
Our NGFP technology supplements BTC diagnostics, distinguishing survival and recurrence subtypes for postoperative and immunotherapy, thereby supporting the development of treatment strategies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
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Neoplasias do Sistema Biliar
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Biomarcadores Tumorais
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Hepatobiliary Pancreat Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China