Rare oxoisoaporphine alkaloids from Menispermum dauricum with potential anti-inflammatory activity.
Phytochemistry
; 225: 114170, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38830388
ABSTRACT
Eleven alkaloids including four previously undescribed oxoisoaporphine alkaloids, menisoxoisoaporphines A-D (1-4), four known analogues (5-8), and three aporphine alkaloids (9-11), were isolated and identified from the rhizomes of Menispermum dauricum. Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses. Among them, compounds 1 and 4 were the first samples of oxoisoaporphine with C-6 isopentylamino moiety, and 2 was a rare C-4 methylation product of oxoisoaporphine alkaloid. The in vitro anti-inflammatory activity of compounds 1-11 was performed by evaluating the inhibition of NO level in LPS-induced RAW264.7 macrophages. Among them, compound 4 exhibited the most potent NO inhibition activity with an IC50 value of 1.95 ± 0.33 µM. The key structure-activity relationships of those oxoisoaporphine alkaloids for anti-inflammatory effects have been summarized.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aporfinas
/
Menispermum
/
Alcaloides
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2024
Tipo de documento:
Article