Molecular landscape and multi-omic measurements of heterogeneity in fetal adenocarcinoma of the lung.
NPJ Precis Oncol
; 8(1): 99, 2024 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-38831114
ABSTRACT
Fetal adenocarcinoma of the lung (FLAC) is a rare form of lung adenocarcinoma and was divided into high-grade (H-FLAC) and low-grade (L-FLAC) subtypes. Despite the existence of some small case series studies, a comprehensive multi-omics study of FLAC has yet to be undertaken. In this study, we depicted the multi-omics landscapes of this rare lung cancer type by performing multi-regional sampling on 20 FLAC cases. A comparison of multi-omics profiles revealed significant differences between H-FLAC and L-FLAC in a multi-omic landscape. Two subtypes also showed distinct relationships between multi-layer intratumor heterogeneity (ITH). We discovered that a lower genetic ITH was significantly associated with worse recurrence-free survival and overall survival in FLAC patients, whereas higher methylation ITH in H-FLAC patients suggested a short survival. Our findings highlight the complex interplay between genetic and transcriptional heterogeneity in FLAC and suggest that different types of ITH may have distinct implications for patient prognosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
NPJ Precis Oncol
Ano de publicação:
2024
Tipo de documento:
Article