Sex differences in mechanisms of pain hypersensitivity.
Neurosci Biobehav Rev
; 163: 105749, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38838876
ABSTRACT
The introduction of sex-as-a-biological-variable policies at funding agencies around the world has led to an explosion of very recent observations of sex differences in the biology underlying pain. This review considers evidence of sexually dimorphic mechanisms mediating pain hypersensitivity, derived from modern assays of persistent pain in rodent animal models. Three well-studied findings are described in detail the male-specific role of spinal cord microglia, the female-specific role of calcitonin gene-related peptide (CGRP), and the female-specific role of prolactin and its receptor. Other findings of sex-specific molecular involvement in pain are subjected to pathway analyses and reveal at least one novel hypothesis:
that females may preferentially use Th1 and males Th2 T cell activity to mediate chronic pain.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caracteres Sexuais
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neurosci Biobehav Rev
Ano de publicação:
2024
Tipo de documento:
Article