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Insulin Inertia Among People With Type 2 Diabetes Mellitus in Qatar: The INERT-Q Study.
Bashir, Mohammed; Thani, Noora Al; Khalid, Abeer; Khalil, Obada; Alamer, Zaina; Hamad, Mohammed Khair; Karuppasamy, Gowri; Abufaeid, Mohammed; Elbidairi, Mutwakil; Al-Mohnnadi, Dhabia; Elhadd, Tarik; Zirie, Mahmoud.
Afiliação
  • Bashir M; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Thani NA; Qatar Metabolic Institutes, Hamad Medical Corporation, Doha, Qatar.
  • Khalid A; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Khalil O; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Alamer Z; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Hamad MK; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Karuppasamy G; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Abufaeid M; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Elbidairi M; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Al-Mohnnadi D; Department of Pharmacy, Hamad Medical Corporation, Doha, Qatar.
  • Elhadd T; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
  • Zirie M; Endocrine Section, Internal Medicine Department, Hamad Medical Corporation, Doha, Qatar.
Endocrinol Diabetes Metab ; 7(4): e00495, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38844642
ABSTRACT

BACKGROUND:

Achieving and maintaining adequate glycaemic control is critical to reduce diabetes-related complications. Therapeutic inertia is one of the leading causes of suboptimal glycaemic control.

AIM:

To assess the degree of inertia in insulin initiation and intensification in people with Type 2 diabetes mellitus (DM-2).

METHODS:

We performed a retrospective longitudinal cohort study and followed DM-2 2 years before and 2 years after the start of insulin. The primary outcome was the proportion of patients who achieved glycaemic targets (HBA1c ≤ 7.5%) at 6th month, 1st year and 2nd year.

RESULTS:

We included 374 predominantly male subjects (62%). The mean age was 55.3 ± 11.3 years, the mean duration of DM-2 was 12.0 ± 7.3 years, 64.4% were obese, 47.6% had a microvascular disease, and 24.3% had a macrovascular disease. The mean HBA1c at -2nd year and -1st year was 9.2 ± 2.1% and 9.3 ± 2.0%, respectively. The mean HbA1C at the time of insulin initiation was 10.4 ± 2.1%. The mean HBA1c at 6th month, 12th month and 2nd year was 8.5 ± 1.8%, 8.4 ± 1.8% and 8.5 ± 1.7%, respectively. The proportion of subjects who achieved HBA1c targets at 6th month, 12th month and 2nd year was 32.9%, 31.0% and 32.9%, respectively. Multivariate logistic regression analysis showed that achieving HBA1c targets at 6th month and 1st year increases the odds of achieving HBA1c targets at 2nd year (OR 4.87 [2.4-9.6] p < 0.001) and (OR 6.2 [3.2-12.0], p < 0.001), respectively.

CONCLUSION:

In people with DM-2, there was an alarming delay in starting and titrating insulin. The reduction in HBA1c plateaued at 6th month. Earlier initiation and intensification of insulin therapy are critical to achieving glycaemic targets. More studies are needed to examine the causes of therapeutic inertia from physicians', patients' and systems' points of view.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas Glicadas / Diabetes Mellitus Tipo 2 / Hipoglicemiantes / Insulina Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Endocrinol Diabetes Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Qatar

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobinas Glicadas / Diabetes Mellitus Tipo 2 / Hipoglicemiantes / Insulina Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Endocrinol Diabetes Metab Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Qatar
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