PD-1 inhibitor plus concurrent chemoradiotherapy for high-risk locally advanced cervical cancer.
Future Oncol
; 20(20): 1415-1426, 2024.
Article
em En
| MEDLINE
| ID: mdl-38861299
ABSTRACT
Aim:
The prognosis of high-risk, locally advanced cervical cancer (LACC) remains poor following concurrent chemoradiotherapy (CCRT). We investigated whether the effect of CCRT can be enhanced by programmed cell death protein 1 (PD-1) inhibitor.Methods:
A retrospective cohort study was conducted to compare the efficacy and safety of CCRT group (n = 82) and PD-1 inhibitor plus CCRT group (n = 70).Results:
Compared with the CCRT group, the PD-1 inhibitor plus CCRT group had significantly higher objective response rate, median progression-free survival, leukopenia and fatigue. The addition of PD-1 inhibitor to CCRT showed a favorable trend in overall survival without statistical significance.Conclusion:
PD-1 inhibitor plus CCRT presented a significant survival benefit and a manageable safety profile in high-risk LACC.
[Box see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
Quimiorradioterapia
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Inibidores de Checkpoint Imunológico
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2024
Tipo de documento:
Article