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Secondary primary malignancies after CD-19 directed CAR-T-cell therapy in lymphomas: A report from the Italian CART-SIE study.
Barone, Angelica; Chiappella, Annalisa; Casadei, Beatrice; Bramanti, Stefania; Ljevar, Silva; Chiusolo, Patrizia; Di Rocco, Alice; Tisi, Maria Chiara; Barbui, Anna Maria; Farina, Mirko; Brunello, Lucia; Di Chio, Maria Chiara; Novo, Mattia; Musso, Maurizio; Olivieri, Jacopo; Trotta, Gentiana Elena; Dodero, Anna; Aiello, Antonella; Corradini, Paolo.
Afiliação
  • Barone A; Chair of Hematology, University of Milan, Milan, Italy.
  • Chiappella A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Casadei B; IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Bramanti S; IRCCS Humanitas Research Hospital, Transplantation Unit Department of Oncology and Haematology, Rozzano, Italy.
  • Ljevar S; Unit of Biostatistics for Clinical Research, Department of Data Science, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Chiusolo P; Dipartimento di Scienze Microbiologiche Ed Ematologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Sezione di Ematologia, Dipartimento di Scienze Radiologiche Ed Ematologiche, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Di Rocco A; Department of Translational and Precision Medicine, 'Sapienza' University of Rome, Rome, Italy.
  • Tisi MC; Hematology Unit, San Bortolo Hospital, Vicenza, Italy.
  • Barbui AM; Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
  • Farina M; Unit of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.
  • Brunello L; SCDU Ematologia AOU SS Antonio e Biagio e Cesare Arrigo Alessandria Italy, Alessandria, Italy.
  • Di Chio MC; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Novo M; Division of Hematology, AOU Città Della Salute e Della Scienza di Torino, Torino, Italy.
  • Musso M; UOC di Oncoematologia e TMO Dipartimento Oncologico La Maddalena Palermo, Palermo, Italy.
  • Olivieri J; Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi", Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.
  • Trotta GE; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Dodero A; Ematologia, Dipartimento di Biomedicina e Prevenzione, Università Degli Studi di Roma Tor Vergata, Rome, Italy.
  • Aiello A; Division of Hematology and Stem Cell Transplantation, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Corradini P; Division of Pathology, Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
Br J Haematol ; 2024 Jun 15.
Article em En | MEDLINE | ID: mdl-38877876
ABSTRACT
Secondary primary malignancies (SPM) have been reported after anti-BCMA or anti-CD19 chimeric antigen receptor (CAR)-T-cell therapies. While the cytotoxic effect of antecedent therapies, including chemotherapy and radiotherapy, has been well established, few data are available on risk related to CAR-T immunotherapies. The study aimed to analyse the incidence of SPM in 651 patients enrolled in the Italian prospective observational CART-SIE study. SPMs were documented in 4.3% (28/651), and the most frequent SPMs were haematological malignancies. In conclusion, the frequency of SPMs in our cohort of heavily pretreated patients receiving CAR-T was relatively low and consistent with previous studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Br J Haematol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Br J Haematol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália