IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy.
Immunohorizons
; 8(6): 431-441, 2024 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-38888412
ABSTRACT
IgE-mediated mast cell (MC) activation is a critical component of allergic responses to oral Ags. Several T cell-derived cytokines have been shown to promote MC reactivity, and we recently demonstrated a critical role for the cytokine IL-10 in mediating MC responses during food allergy. In this study, we further validate the role of IL-10 using Ab-mediated IL-10 depletion. IL-10 neutralization significantly attenuated MC responses, leading to decreased MC accumulation and activation, as well as inhibition of MC-mediated symptoms such as allergic diarrhea. This was accompanied by decreased Th2 cytokine gene expression, attenuated systemic T cell responses, and fewer CD4 T cells, B cells, and MCs in the spleen. Our data further confirm the role of IL-10 in driving MC responses and suggest that IL-10-responsive MCs may constitute an important player in allergic responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucina-10
/
Modelos Animais de Doenças
/
Hipersensibilidade Alimentar
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Immunohorizons
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Marrocos