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Synthesis and Application of a pH-Responsive Functional Metal-Organic Framework: In Vitro Investigation for Delivery of Oridonin in Cancer Therapy.
Shen, Jingyi; Gao, Fangxin; Pan, Qian; Zong, Zhihui; Liang, Lili.
Afiliação
  • Shen J; Department of Pharmaceutical Engineering, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Donghai Avenue, Bengbu 233030, China.
  • Gao F; Department of Pharmaceutical Engineering, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Donghai Avenue, Bengbu 233030, China.
  • Pan Q; Department of Pharmaceutical Engineering, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Donghai Avenue, Bengbu 233030, China.
  • Zong Z; Department of Pharmaceutical Engineering, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Donghai Avenue, Bengbu 233030, China.
  • Liang L; Department of Pharmaceutical Engineering, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical University, Donghai Avenue, Bengbu 233030, China.
Molecules ; 29(11)2024 Jun 04.
Article em En | MEDLINE | ID: mdl-38893518
ABSTRACT
Oridonin (Ori) is a naturally existing diterpenoid substance that mainly exists in the Chinese medicinal plant Rabdosia rubescens. It was previously found to possess intriguing biological properties; however, the quick clearance from plasma and limited solubility in water restricts its use as a drug. Several metal-organic frameworks (MOFs), having big surfaces and large pores, have recently been considered promising drug transporters. The zeolitic imidazolate framework-8 (ZIF-8), a form of MOF consisting of 2-methylimidazole with zinc ions, is structurally stable under physiologically neutral conditions, while it can degrade at low pH values such as in tumor cells. Herein, a nanosized drug delivery system, Ori@ZIF-8, was successfully designed for encapsulating and transporting oridonin to the tumor site. The drug loading of the prepared Ori@ZIF-8 was 26.78%, and the particles' mean size was 240.5 nm. In vitro, the release of Ori@ZIF-8 exhibited acid sensitivity, with a slow release under neutral conditions and rapid release of the drug under weakly acidic conditions. According to the in vitro anti-tumor experiments, Ori@ZIF-8 produced higher cytotoxicity than free Ori and induced apoptosis in A549 cancer cells. In conclusion, Ori@ZIF-8 could be a potential pH-responsive carrier to accurately release more oridonins at the tumor site.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diterpenos do Tipo Caurano / Estruturas Metalorgânicas Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diterpenos do Tipo Caurano / Estruturas Metalorgânicas Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
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