Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection.
Nanomedicine (Lond)
; 19(15): 1369-1388, 2024 06 20.
Article
em En
| MEDLINE
| ID: mdl-38900630
ABSTRACT
Aim:
Our investigation aims to estimate the antifungal effect of propranolol hydrochloride (PNL).Methods:
Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and amount of drug released after 6 h Q6h (%).Results:
The optimal OL showed a rounded shape with optimum characteristics. The ex-vivo permeation and confocal laser scanning microscopy verified the prolonged release and well deposition of PNL-loaded OLs-gel. The in-silico assessment demonstrated the good stability of PNL with OLs' ingredients. In vivo evaluations for PNL-loaded OLs-gel showed a good antifungal impact against Candida albicans with good safety.Conclusion:
This work highlights the potential of PNL-loaded OLs-gel as a potential treatment for candida vaginal infection.
[Box see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Candida albicans
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Hidrogéis
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Quitosana
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Antifúngicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Egito