Associations of systemic immune-inflammation index with high risk for prostate cancer in middle-aged and older US males: A population-based study.
Immun Inflamm Dis
; 12(6): e1327, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38923408
ABSTRACT
BACKGROUND:
Systemic immune-inflammation index (SII) provides convincing evaluation of systemic immune and inflammatory condition in human body. Its correlation with prostate cancer (PCa) risk remains uncharted. The principal objective of this investigation was to elucidate the association between SII and the risk for PCa in middle-aged and elderly males. MATERIALS ANDMETHODS:
Analysis entailed multivariate linear and logistic regression, generalized additive model, and smoothing curve fitting using resource from 2007 to 2010 National Health and Nutrition Examination Survey (NHANES). To ascertain robustness and consistency of this association across different demographic strata, we conducted rigorous subgroup analyses and interaction tests.RESULTS:
Among 3359 participants, those with elevated SII displayed higher total prostate-specific antigen (tPSA) levels, higher risk for PCa, and lower free/total PSA (f/t PSA) ratio. Specifically, each unit increase of log2 (SII) was associated with a 0.22 ng/mL increase in tPSA (ß 0.22, 95% confidence intervals [CI] 0.05-0.38), a 2.22% decline in f/t PSA ratio (ß -2.22, 95% CI -3.20 to -1.23), and a 52% increased odds of being at high risk for PCa (odds ratio [OR] 1.52, 95% CI 1.13-2.04). People in the top quartile of log2 (SII) exhibited 0.55 ng/mL increased tPSA (ß 0.55, 95% CI 0.19-0.90), 4.39% reduced f/t PSA ratio (ß -4.39, 95% CI -6.50 to -2.27), and 168% increased odds of being at high risk for PCa (OR 2.68, 95% CI 1.32-5.46) compared to those in the bottom quartile.CONCLUSION:
Systemic immune and inflammatory condition, as represented by SII, is independently and positively associated with tPSA levels and the risk for PCa, as well as independently and negatively associated with f/t PSA ratio among middle-aged and older US males. These findings may enhance the effectiveness of PCa screening in predicting positive biopsy results.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Inquéritos Nutricionais
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Antígeno Prostático Específico
/
Inflamação
Limite:
Aged
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Humans
/
Male
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Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Immun Inflamm Dis
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China