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Poly-l-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess The Morphology, Thermal Behavior, and Hydrophilicity.
Schiera, Veronica; Carfì Pavia, Francesco; La Carrubba, Vincenzo; Brucato, Valerio; Dintcheva, Nadka Tz.
Afiliação
  • Schiera V; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Ed. 6, 90128 Palermo, Italy.
  • Carfì Pavia F; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Ed. 6, 90128 Palermo, Italy.
  • La Carrubba V; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Ed. 6, 90128 Palermo, Italy.
  • Brucato V; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Ed. 6, 90128 Palermo, Italy.
  • Dintcheva NT; Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Ed. 6, 90128 Palermo, Italy.
Polymers (Basel) ; 16(12)2024 Jun 12.
Article em En | MEDLINE | ID: mdl-38932024
ABSTRACT
This study aims to demonstrate the possibility of incorporating a natural antioxidant biomolecule into polymeric porous scaffolds. To this end, Poly-l-Lactic Acid (PLLA) scaffolds were produced using the Thermally Induced Phase Separation (TIPS) technique and additivated with different amounts of rosmarinic acid (RA). The scaffolds, with a diameter of 4 mm and a thickness of 2 mm, were characterized with a multi-analytical approach. Specifically, Scanning Electron Microscopy analyses demonstrated the presence of an interconnected porous network, characterized by a layer of RA at the level of the pore's surfaces. Moreover, the presence of RA biomolecules increased the hydrophilic nature of the sample, as evidenced by the decrease in the contact angle with water from 128° to 76°. The structure of PLLA and PLLA containing RA molecules has been investigated through DSC and XRD analyses, and the obtained results suggest that the crystallinity decreases when increasing the RA content. This approach is cost-effective, and it can be customized with different biomolecules, offering the possibility of producing porous polymeric structures containing antioxidant molecules. These scaffolds meet the requirements of tissue engineering and could offer a potential solution to reduce inflammation associated with scaffold implantation, thus improving tissue regeneration.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Polymers (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Polymers (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália
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