Development of fexofenadine self-microemulsifying delivery systems: an efficient way to improve intestinal permeability.
Ther Deliv
; 15(8): 593-604, 2024.
Article
em En
| MEDLINE
| ID: mdl-38941109
ABSTRACT
Aim:
The present study aimed to prepare and evaluate fexofenadine self-microemulsifying drug-delivery systems (SMEDDS) formulation and to determine and compare its intestinal permeability using in situ single-pass intestinal perfusion (SPIP) technique.Methods:
Fexofenadine-loaded SMEDDS were prepared and optimized. Droplet size, polydispersity index, zeta potential, drug release and intestinal permeability were evaluated.Results:
Optimized formulation consisted of 15% oil, 80% surfactant and 5% cosolvent. Droplet size and drug loading of optimized formulation was 13.77 nm and 60 mg/g and it has released 90% of its drug content. Intestinal permeability of fexofenadine was threefold enhanced in SMEDDS compared with free fexofenadine.Conclusion:
The results of our study revealed that SMEDDS could be a promising tool for oral delivery of fexofenadine with enhanced dissolution rate and intestinal permeability.
[Box see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Permeabilidade
/
Terfenadina
/
Sistemas de Liberação de Medicamentos
/
Emulsões
/
Absorção Intestinal
Limite:
Animals
Idioma:
En
Revista:
Ther Deliv
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Irã