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Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives.
Couacault, Pauline; Avella, Dennisse; Londoño-Osorio, Sara; Lorenzo, Ana S; Gradillas, Ana; Kärkkäinen, Olli; Want, Elizabeth; Witting, Michael.
Afiliação
  • Couacault P; Metabolomics and Proteomics Core Helmholtz Zentrum München Neuherberg Germany.
  • Avella D; Afekta Technologies Ltd. Kuopio Finland.
  • Londoño-Osorio S; School of Pharmacy Faculty of Health Sciences University of Eastern Finland Kuopio Finland.
  • Lorenzo AS; Centro de Metabolómica y Bioanálisis (CEMBIO) Facultad de Farmacia Universidad San Pablo-CEU CEU Universities Urbanización Montepríncipe Boadilla del Monte Madrid Spain.
  • Gradillas A; Department of Metabolism Digestion and Reproduction Imperial College London London UK.
  • Kärkkäinen O; Centro de Metabolómica y Bioanálisis (CEMBIO) Facultad de Farmacia Universidad San Pablo-CEU CEU Universities Urbanización Montepríncipe Boadilla del Monte Madrid Spain.
  • Want E; Afekta Technologies Ltd. Kuopio Finland.
  • Witting M; School of Pharmacy Faculty of Health Sciences University of Eastern Finland Kuopio Finland.
Anal Sci Adv ; 5(5-6): e2400002, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38948320
ABSTRACT
Blood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non-systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Anal Sci Adv Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Anal Sci Adv Ano de publicação: 2024 Tipo de documento: Article
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