Factors influencing the reimbursement of cancer drugs in Europe: A scoping review.
J Eval Clin Pract
; 2024 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-38959379
ABSTRACT
RATIONALE Reimbursement process of oncology drugs in Europe occurs within a complex decision-making process that varies between Member States. Distinctions between the States trigger societal debates since it is necessary to balance access to medicines and health systems sustainability. AIMS AND OBJECTIVES:
We aimed to review the evidence concerning factors associated with the reimbursement decision or Health Technology Agency recommendation of oncology drugs in Europe.METHODS:
A systematic literature search was performed in two databases from inception to august 2023. Screening and data extraction were performed by pairs.RESULTS:
Thirteen articles were included and encompassed data from 11 nations. Seven articles showed that cost-effective (C-E) drugs and lower Incremental Cost-Effectiveness Ratios (ICERs) had higher likelihood of reimbursement. Disease severity might influence the reimbursement decision with financial agreements. Improvement in clinical outcomes, substantial clinical benefit (p < 0.01) or overall survival gains (p < 0.05) were positively associated. Orphan drug designation impact varies between countries but positive decisions are usually achieved under specific conditions. Clinical and C-E uncertainty frequently led to reimbursement with financial agreements or outcomes-based conditions. Sociodemographic factors as social health insurance system, higher Gross Domestic Product and larger elderly population were positively associated with reimbursement (p < 0.01).CONCLUSION:
There is a need for further research into key determinants of reimbursement decisions in Europe and the development of drug access models that can effectively address and overcome costs and effectiveness uncertainties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Eval Clin Pract
Assunto da revista:
PESQUISA EM SERVICOS DE SAUDE
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha