Exploiting Matrix Stiffness to Overcome Drug Resistance.
ACS Biomater Sci Eng
; 10(8): 4682-4700, 2024 Aug 12.
Article
em En
| MEDLINE
| ID: mdl-38967485
ABSTRACT
Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the related signal transduction pathways can provide a better understanding for developing novel therapeutic strategies. In this review, we aimed to summarize the recent advancements in tumor matrix biology in parallel to therapeutic approaches targeting matrix stiffness and its consequences in cellular processes in tumor progression and metastasis. The cellular processes governed by signal transduction pathways and their aberrant activation may result in activating the epithelial-to-mesenchymal transition, cancer stemness, and autophagy, which can be attributed to drug resistance. Developing therapeutic strategies to target these cellular processes in cancer biology will offer novel therapeutic approaches to tailor better personalized treatment modalities for clinical studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistencia a Medicamentos Antineoplásicos
/
Mecanotransdução Celular
/
Matriz Extracelular
/
Transição Epitelial-Mesenquimal
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Biomater Sci Eng
/
ACS biomater. sci. eng
/
ACS biomaterials science & engineering
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Turquia