[Quantitative Activity-Induced Manganese-Enhanced Magnetic Resonance Imaging: Principles, Applications, and Limitations].

ABSTRACT

Accurate identification of regions that show activity changes in response to functional expression is necessary to understand the mechanisms underlying functional expression in the brain. Quantitative activity-induced manganese-enhanced magnetic resonance imaging (qAIM-MRI) is a noninvasive whole-brain activity history imaging method used for this purpose. Notably, qAIM-MRI is a pseudo-Ca2+ imaging method that uses Mn2+ as a surrogate marker for Ca2+. In this paper, I describe the principles, applications, and limitations of qAIM-MRI.