Crisis in the gut: navigating gastrointestinal challenges in Gulf War Illness with bioengineering.
Mil Med Res
; 11(1): 45, 2024 Jul 08.
Article
em En
| MEDLINE
| ID: mdl-38978144
ABSTRACT
Gulf War Illness (GWI) is characterized by a wide range of symptoms that manifests largely as gastrointestinal symptoms. Among these gastrointestinal symptoms, motility disorders are highly prevalent, presenting as chronic constipation, stomach pain, indigestion, diarrhea, and other conditions that severely impact the quality of life of GWI veterans. However, despite a high prevalence of gastrointestinal impairments among these veterans, most research attention has focused on neurological disturbances. This perspective provides a comprehensive overview of current in vivo research advancements elucidating the underlying mechanisms contributing to gastrointestinal disorders in GWI. Generally, these in vivo and in vitro models propose that neuroinflammation alters gut motility and drives the gastrointestinal symptoms reported in GWI. Additionally, this perspective highlights the potential and challenges of in vitro bioengineering models, which could be a crucial contributor to understanding and treating the pathology of gastrointestinal related-GWI.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Golfo Pérsico
/
Bioengenharia
/
Gastroenteropatias
Limite:
Humans
Idioma:
En
Revista:
Mil Med Res
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos