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Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review.
Tuo, Zhouting; Zhang, Ying; Li, Dengxiong; Wang, Yetong; Wu, Ruicheng; Wang, Jie; Yu, Qingxin; Ye, Luxia; Shao, Fanglin; Wusiman, Dilinaer; Yang, Yubo; Yoo, Koo Han; Ke, Mang; Okoli, Uzoamaka Adaobi; Cho, William C; Heavey, Susan; Wei, Wuran; Feng, Dechao.
Afiliação
  • Tuo Z; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
  • Zhang Y; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
  • Li D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang Y; The Fourth Corps of Students of the Basic Medical College, Army Medical University, Chongqing 400038, China.
  • Wu R; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang J; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yu Q; Department of Pathology, Ningbo Clinical Pathology Diagnosis Center, Ningbo City, Zhejiang Province 315211, China.
  • Ye L; Department of Public Research Platform, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.
  • Shao F; Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
  • Wusiman D; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
  • Yang Y; Department of Urology, Three Gorges Hospital, Chongqing University, Chongqing, Wanzhou 404000, China.
  • Yoo KH; Department of Urology, Kyung Hee University, South Korea.
  • Ke M; Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, China.
  • Okoli UA; Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK; Basic and Translational Cancer Research Group, Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria.
  • Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR China. Electronic address: williamcscho@gmail.com.
  • Heavey S; Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK. Electronic address: s.heavey@ucl.ac.uk.
  • Wei W; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: weiwuran@scu.edu.cn.
  • Feng D; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China; Division of Surgery & Interventional Science, University College London, London W1W 7TS, UK. Electronic address: dechao.feng@ucl.ac.uk.
Pharmacol Res ; 206: 107302, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39004242
ABSTRACT
Bladder cancer stands as a prevalent global malignancy, exhibiting notable sex-based variations in both incidence and prognosis. Despite substantial strides in therapeutic approaches, the formidable challenge of drug resistance persists. The genomic landscape of bladder cancer, characterized by intricate clonal heterogeneity, emerges as a pivotal determinant in fostering this resistance. Clonal evolution, encapsulating the dynamic transformations within subpopulations of tumor cells over time, is implicated in the emergence of drug-resistant traits. Within this review, we illuminate contemporary insights into the role of clonal evolution in bladder cancer, elucidating its influence as a driver in tumor initiation, disease progression, and the formidable obstacle of therapy resistance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Resistencia a Medicamentos Antineoplásicos / Genômica / Evolução Clonal Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Resistencia a Medicamentos Antineoplásicos / Genômica / Evolução Clonal Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article