GP consultations for menstrual disorders after COVID-19 vaccination - A self-controlled cohort study based on routine healthcare data from the Netherlands.
Vaccine
; 42(25): 126130, 2024 Nov 14.
Article
em En
| MEDLINE
| ID: mdl-39004527
ABSTRACT
INTRODUCTION:
Several studies described that COVID-19 vaccinations can cause menstrual disorders. Our study aimed to describe whether this also resulted in more general practitioner (GP) consultations for menstrual disorders after COVID-19 vaccination, based on a large cohort study.METHODS:
A retrospective self-controlled cohort study was performed including vaccinated women in 2021 aged 12-49 years from two large, representative GP databases in the Netherlands. Incidence rates and incidence rate ratio's (IRR) were calculated using Poisson regression, adjusting for SARS-CoV-2 infection as time-varying confounder. The exposed period was set at maximum six months after each COVID-19 vaccination and the non-exposed period was defined as all-time outside the exposed period.RESULTS:
The cohort included 631,802 women, of which 18,986 (3 %) consulted the GP for a menstrual disorder during 2021. Increased GP consultations were observed among 12-14 year olds for amenorrhea/hypomenorrhea/oligomenorrhea (IRR 1.85, 95 % CI 1.30-2.65) and irregular/frequent menstruation (IRR 1.33, 95 % CI 1.06-1.69) after COVID-19 vaccination in general, and after Pfizer/BioNTech vaccination (IRR 1.87, 95 % CI 1.31-2.67 for amenorrhea/hypomenorrhea/oligomenorrhea and IRR 1.35, 95 % CI 1.06-1.70 for irregular/frequent menstruation). Persons from this age group were in general also vaccinated with Pfizer/BioNTech. No increase in the frequency of GP consultations were observed for older age groups, other vaccine brands, and potential risk groups.CONCLUSION:
For the majority of women, no increased GP consultations for menstrual disorders was found. Solely for the youngest age group (12-14 year olds) increased GP consultations for specific types of menstrual disorders was found after Pfizer/BioNTech vaccination.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinação
/
Vacinas contra COVID-19
/
COVID-19
Limite:
Adolescent
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Adult
/
Child
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Holanda