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Value of prognostic nutritional index and controlling nutritional status score for advanced non-small cell lung cancer patients receiving PD-1 inhibitors.
Jiang, Sicong; Wang, Xuefeng; Xing, Yuxuan; Wu, Jiahao; Yuan, Xiya.
Afiliação
  • Jiang S; Department of Oncology, Shenzhen Hospital of Guangzhou University of Chinese Medicine Shenzhen 518034, Guangdong, China.
  • Wang X; Division of Thoracic and Endocrine Surgery, University Hospitals and University of Geneva Geneva 1211, Switzerland.
  • Xing Y; Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Qingdao 266003, Shandong, China.
  • Wu J; Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University Suzhou 215000, Jiangsu, China.
  • Yuan X; Department of General Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou 510700, Guangdong, China.
Am J Cancer Res ; 14(6): 2894-2904, 2024.
Article em En | MEDLINE | ID: mdl-39005673
ABSTRACT

OBJECTIVE:

To explore the value of preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score in predicting response and prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving programmed cell death protein 1 (PD-1) inhibitors.

METHODS:

A retrospective study was conducted in patients who received PD-1 inhibitors for advanced NSCLC. Patients were assigned by immunotherapy effects into response (partial and complete response, pCR) group (n=52) and non-response (non-pCR) group (n=132). The pathological and clinical data were collected for statistical analysis of factors influencing the immunotherapeutic response. The diagnostic value of PNI and CONUT score for response was assessed. The overall survival (OS) was observed over a 3-year follow-up. COX regression analysis was performed to identify risk factors affecting the survival. The effects of different PNI and CONUT scores on the survival were observed.

RESULTS:

Multivariate regression analysis showed that, the tumor-node-metastasis (TNM) stage (P=0.001), PNI (P<0.001), and CONUT score (P<0.001) were associated with response. The non-pCR group had a higher 3-year mortality rate and a shorter 3-year OS than the pCR group (P<0.001). COX regression analysis showed that low PNI and high CONUT score were risk factors for poor prognosis. Further analysis showed that patients with low PNI and high CONUT score had lower 3-year survival rates (P=0.005, P<0.001).

CONCLUSION:

High TNM stage, PNI<50, and CONUT score ≥5 are risk factors for poor response in patients with advanced NSCLC receiving PD-1 inhibitors, and low PNI and high CONUT score suggest poor prognosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Cancer Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Am J Cancer Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
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