Emerging role of local treatment in the era of advanced systemic treatment in pancreatic cancer with liver metastasis: A systematic review and meta-analysis.
J Hepatobiliary Pancreat Sci
; 31(9): 601-610, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39020260
ABSTRACT
BACKGROUND:
Approximately 50% of pancreatic cancer cases are diagnosed with distant metastases, commonly in the liver, leading to poor prognosis. With modern chemotherapy regimens extending patient survival and stabilizing metastasis, there has been a rise in the use of local treatments. However, the effectiveness for local treatment remains unclear.METHODS:
PubMed, Embase, and Cochrane databases were searched for studies reporting the survival outcomes of pancreatic cancer cases with isolated synchronous or metachronous liver metastases who underwent curative-intent local treatment. Hazard ratios were combined using a random-effects model.RESULTS:
The full texts of 102 studies were screened, and 14 retrospective studies were included in the meta-analysis. Among patients with synchronous liver metastases, overall survival was significantly better in those who underwent curative-intent local treatment than in those who did not (hazard ratio [HR] 0.35, 95% confidence interval [CI] 0.24-0.52). Among patients with metachronous liver metastases, overall survival was also significantly better in those who underwent curative-intent local treatment than in those who did not (HR 0.37, 95% CI 0.19-0.73).CONCLUSIONS:
Curative-intent local treatment may be a feasible option for highly selected pancreatic cancer cases with liver metastases. However, the optimal strategy for local treatments should be explored in future studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
En
Revista:
J Hepatobiliary Pancreat Sci
/
J. hepato-biliary-pancreat. sci. (Internet)
/
Journal of hepato-biliary-pancreatic sciences (Internet)
Ano de publicação:
2024
Tipo de documento:
Article