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Water soluble curcumin with alkyl sulfonate moiety: Synthesis, and anticancer efficacy.
Janem, Alaa; Omar, Ghader; Hamed, Othman; Jodeh, Shehdeh; Deghles, Abdalhadi; Berisha, Avni; Mansour, Waseem; Jabal, Saber Abu; Fares, Oswa; Jaser, Ataa; Amireh, Ameed; Adwan, Ghaleb.
Afiliação
  • Janem A; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Omar G; Biology Department, Faculty of Sciences An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Hamed O; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Jodeh S; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Deghles A; Department of Chemistry, Istiqlala University, Jericho, Palestine.
  • Berisha A; Department of Chemistry, Faculty of Natural and Mathematics Science, University of Prishtina, Prishtina, 10000, Republic of Kosovo.
  • Mansour W; Materials Science-Nanochemistry Research Group, Nano Alb-Unit of Albanian Nanoscience and Nanotechnology, Tirana, 1000 Albania.
  • Jabal SA; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Fares O; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Jaser A; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Amireh A; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
  • Adwan G; Chemistry Department, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Heliyon ; 10(13): e33808, 2024 Jul 15.
Article em En | MEDLINE | ID: mdl-39040342
ABSTRACT
Curcumin is classified as a chemotherapeutic medication because of its potential against numerous cancer cell lines and ability to inhibit cancer cell proliferation. Despite these findings, curcumin has yet to be commercialized as a drug due to its low water solubility, low absorption, and restricted bioavailability. As a result, there is a demand for water-soluble curcumin with improved solubility, bioavailability, and thus bioactivity. In this study we report the synthesis and the anticancer activities of water-soluble curcumins derivatives with alkyl sulfonate moiety. The target water-soluble curcumin with alkyl sulfonate moieties was created utilizing a straightforward technique that involved reacting curcumin with various sultones. The cytotoxic (24 h) and cytostatic (72 h) anticancer effect on breast carcinoma (MCF-7), liver carcinoma (HepG2), skin melanoma (B16-F110), colon human cancer and HeLa cervical carcinoma cell lines viability % via MTT assay were determined for the prepared derivatives. Results showed that curcumin-derived compounds have a pronounced cytostatic anticancer effect rather than cytotoxic one in relation to the compound type, cancer cell line type, and examined concentration compared to curcumin. The curcumin sulfonates outperformed curcumin activity against the tested cancer cells and showed to be powerful anticancer candidate drugs as supported by the theoretical calculations. This is evident by their high capacity to form H-bonding during docking with the amino acid side chains and the Vina docking score.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2024 Tipo de documento: Article
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