Role of antioxidants in modulating anti-tumor T cell immune resposne.
Adv Cancer Res
; 162: 99-124, 2024.
Article
em En
| MEDLINE
| ID: mdl-39069371
ABSTRACT
It has been well established that in addition to oxygen's vital in cellular respiration, a disruption of oxygen balance can lead to increased stress and oxidative injury. Similarly, reduced oxygen during tumor proliferation and invasion generates a hypoxic tumor microenvironment, resulting in dysfunction of immune cells and providing a conducive milieu for tumors to adapt and grow. Strategies to improve the persistence tumor reactive T cells in the highly oxidative tumor environment are being pursued for enhancing immunotherapy outcomes. To this end, we have focused on various strategies that can help increase or maintain the antioxidant capacity of T cells, thus reducing their susceptibility to oxidative stress/damage. Herein we lay out an overview on the role of oxygen in T cell signaling and how pathways regulating oxidative stress or antioxidant signaling can be targeted to enhance immunotherapeutic approaches for cancer treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Microambiente Tumoral
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Neoplasias
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Antioxidantes
Limite:
Animals
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Humans
Idioma:
En
Revista:
Adv Cancer Res
/
Adv. cancer res
/
Advances in cancer research
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos