Tröger's Base-Embedded PillararenesâMacrocycles with Both Fixed and Conformational Chirality.

Shi, Conghao; Li, Heng; Xie, Wang; Wang, Ranran; Wang, Xiaoqi; Lu, Xiancai; Lin, Chen; Jiang, Juli; Wang, Leyong

Tröger's Base-Embedded PillararenesâMacrocycles with Both Fixed and Conformational Chirality.

Shi, Conghao; Li, Heng; Xie, Wang; Wang, Ranran; Wang, Xiaoqi; Lu, Xiancai; Lin, Chen; Jiang, Juli; Wang, Leyong.

Afiliação

Shi C; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Li H; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Xie W; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Wang R; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Wang X; School of History, Nanjing University, Nanjing 210023, China.
Lu X; Key Lab of Surficial Geochem of MOE, School of Earth Science and Engineering, Nanjing University, Nanjing 210023, China.
Lin C; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Jiang J; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Wang L; Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Org Lett ; 26(32): 6910-6914, 2024 Aug 16.

Article em En | MEDLINE | ID: mdl-39110602

ABSTRACT

ABSTRACT

Tröger's base-embedded pillararenes (P[1]TB[3]A), which combine Tröger's base (TB) with dialkoxybenzene units, were prepared via a fragment-coupling macrocyclization strategy. The TB unit in macrocycle P[1]TB[3]A provides a fixed chiral source, while 1,4-alkoxybenzene segments flip quickly to change their arrangement, which could provide reversible conformational chirality for those macrocycles. This rare example of macrocycles holding both fixed and conformational chirality lays a good foundation for expanding pillararenes using the fixed chiral source.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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