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Boronic acid-functionalized magnetic covalent organic frameworks based solid-phase extraction coupled with hydrophilic interaction chromatography-tandem mass spectrometry for the determination of trace gentamicin residues in milk.
Cao, Hao; Li, Yang; Feng, Jianan; Cao, Yiqing; Xiang, Yangjiayi; Li, Yan.
Afiliação
  • Cao H; Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China.
  • Li Y; Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China.
  • Feng J; School of Pharmacy, Shanghai University of Medicine & Health Sciences, 201318, China.
  • Cao Y; Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China.
  • Xiang Y; Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China; Department of Pharmacy, Jing'an District Central Hospital of Shanghai, Shanghai, 200040, China.
  • Li Y; Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University, Shanghai, 201203, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201203, China. Electronic address: yanli@fudan.edu.cn.
Talanta ; 279: 126678, 2024 Aug 06.
Article em En | MEDLINE | ID: mdl-39116731
ABSTRACT
Boric acid-functionalized magnetic covalent organic frameworks (Fe3O4-TpBD-B) with large surface area and high porosity were prepared and applied for magnetic solid-phase extraction adsorbent of gentamicin from milk before UPLC-MS/MS detection. By utilizing a new HILIC chromatographic column with zwitterionic sulfoalkyl betaine stationary phase based on ethyl bridged hybrid particles (BEH), isomers of gentamicin (C1, C1a, and C2+C2a components). The developed methods demonstrated good linearity (R2 > 0.99), acceptable accuracy and good precision (<10 %), and low limit of quantitation (1.59 ng mL⁻1 for C1, 1.52 ng mL⁻1 for C1a and 2.72 ng mL⁻1 for C2+C2a). In addition, this method has been effectively applied to the analysis of real milk samples.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Talanta Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Talanta Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
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