Catalyst-Controlled [3 + 2] Annulation of Allenes with N-Monosubstituted Hydroxylamines for Regioselective Synthesis of Two Types of Isomeric Isoxazolidines.
Org Lett
; 2024 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-39163647
ABSTRACT
Catalyst-controlled regioselective [3 + 2] cascade annulation of allenes with N-monosubstituted hydroxylamines for precise construction of two types of isoxazolidine regiomers has been developed. The Ce(OTf)3 and MgCl2 can guide the nitrogen and oxygen atoms of N-hydroxyarylamides to both ends of the consecutive double bond of allenes, respectively, to afford two kinds of isomeric products. Notably and remarkably, the consecutive double bond of allenes served as a C3 synthon.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2024
Tipo de documento:
Article