Development of a hybrid rhodamine-hydrazine NIR fluorescent probe for sensitive detection and imaging of peroxynitrite in necrotizing enterocolitis model.
Bioorg Chem
; 152: 107729, 2024 Nov.
Article
em En
| MEDLINE
| ID: mdl-39178703
ABSTRACT
This study describes the synthesis and characterization of a novel near-infrared (NIR) fluorescent probe RBNE based on a hybrid rhodamine dye, which shows excellent optical capability for detecting and imaging ONOO- in necrotizing enterocolitis (NEC) mouse model. The probe RBNE undergoes hydrazine redox-process, and subsequently the spirocyclic structure's opening, resulting in a turn-on fluorescence emission with the presence of ONOO-, which exhibits several excellent features, including a significant Stokes shift of 108 nm, near-infrared emission at 668 nm, a lower detection limit of 56 nM, low cytotoxicity, and excellent imaging ability for ONOO- both in vitro and in vivo. The presented study introduces a novel optical tool that has the potential to significantly advance our understanding of peroxynitrite (ONOO-) behaviors in necrotizing enterocolitis (NEC).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rodaminas
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Enterocolite Necrosante
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Ácido Peroxinitroso
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Corantes Fluorescentes
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Hidrazinas
Limite:
Animals
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Humans
Idioma:
En
Revista:
Bioorg Chem
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Bioorganic chem
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Bioorganic chemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China