Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption.
ACS Chem Biol
; 19(9): 2032-2040, 2024 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-39225324
ABSTRACT
This research presents a unique small molecule characterized by its ability to effectively disrupt RNA G-quadruplexes (G4s), which are notably more stable than their DNA counterparts. We conducted a comprehensive series of in vitro experiments to thoroughly assess the disruptive capabilities of this molecule on RNA G4s. These experiments included comparisons with established G4 stabilizers and DNA G4 disruptors, providing a multifaceted evaluation of the molecule's efficacy. Our extensive in vitro analyses demonstrated that this molecule effectively alters G4 structures and interactions with the BG4 protein, a well-recognized G4-specific antibody. These findings underscore the molecule's potential to modulate G4-protein interactions, indicating promising applications for manipulating cellular functions associated with G4 dynamics in future research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
RNA
/
Quadruplex G
Limite:
Humans
Idioma:
En
Revista:
ACS Chem Biol
/
ACS chem. biol. (Online)
/
ACS chemical biology (Online)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China