Reactivation of allergic encephalomyelitis by means of allogeneic confrontation.
Cell Immunol
; 90(2): 614-9, 1985 Feb.
Article
em En
| MEDLINE
| ID: mdl-3967305
ABSTRACT
Lewis rats recovered from experimental allergic encephalomyelitis (EAE) are resistant to active reinduction of disease. (DA X Lewis)F1 hybrids behave in an identical fashion. The induction of a graft versus host (GVH) reaction in EAE convalescent (DA X Lewis)F1 rats, by injection of normal parental (Lewis) lymphocytes, precipitates a second episode of EAE in a proportion of rats. This secondary episode of EAE can be induced by injection of parental cells either systemically (intravenously) or locally (subcutaneously in the foot). A host versus graft (HVG) reaction does not reactivate EAE in the convalescent host. The observed effect is probably due to reactivation of EAE effector cells following the extensive nonspecific proliferation of host lymphoid cells which is a feature of GVH reactivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Linfócitos
/
Encefalomielite Autoimune Experimental
/
Reação Enxerto-Hospedeiro
Limite:
Animals
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
1985
Tipo de documento:
Article