Strain dependence of the antiproliferative action of interferon on murine erythroid precursors.
Science
; 209(4453): 292-3, 1980 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-6155700
ABSTRACT
Electrophoretically pure mouse interferon inhibits erythropoietin-dependent proliferation of committed erythroid precursors (CFU-E) obtained either from adult mouse bone marrow or from 14-day fetal mouse livers. The degree of inhibition is significantly influenced by the genotype of the cell donor; about ten times as much interferon is required to inhibit proliferation of CFU-E from C57BL/6 than is needed for comparable inhibition of CFU-E from BALB/c or Swiss mice. These strain-dependent results point to the existence of genes that influence the degree of the inhibitory effect of interferon on cell multiplication.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Interferons
/
Eritropoese
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1980
Tipo de documento:
Article