Nomifensine antagonizes the ouabain-induced increase in dopamine metabolites in cerebrospinal fluid of the rat.
Eur J Pharmacol
; 90(2-3): 279-82, 1983 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-6192001
ABSTRACT
The effect of the Na+, K+-ATPase inhibitor, ouabain, on cerebrospinal fluid dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) levels was studied in pentobarbitone-anesthetized rats. An intracerebroventricular injection of ouabain (100 nmol) dramatically increased DOPAC and HVA levels. A dopamine uptake inhibitor, nomifensine (10 mg/kg i.p.) injected prior to ouabain, completely abolished the effect of ouabain on dopamine metabolites. These results are in agreement with the ouabain-induced increase in dopamine efflux described in vitro and favour the role of a carrier-mediated cytosolic release of dopamine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ouabaína
/
Dopamina
/
Nomifensina
/
Isoquinolinas
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1983
Tipo de documento:
Article