The risks of small intestinal transplantation for the recipient: experimental results in young minipigs.
J Pediatr Surg
; 13(6): 465-7, 1978 Oct.
Article
em En
| MEDLINE
| ID: mdl-712518
ABSTRACT
In a previous series of 36 small intestinal transplants in young minipigs, a monitoring system, based on a special transplantation model, clinical and histologic criteria has been worked out. The spontaneous evolution was observed and no attempt was made to save the animal when complications on the graft occurred. Most of the animals died. In the present series of 32 small intestinal transplants the monitoring system and explanation criteria are now tested. Twenty-three primarily successfully transplanted animals had complications of the graft, i.e., hemorrhagic infarction, deficient arterial circulation, or rejection. Only 1 of the 23 died before explanation could be done. Twenty-two were explanted according to the previously established criteria. Two died of complications not directly related to the graft, the other 20 animals survived for 1-5 mo. All 22 explanted grafts showed irreversible damages both macroscopically and on histologic examination. The present series confirms that early recognition of complications of the graft and timely removal with survival of the recipient animal is possible. This could be an important step forward to the clinical application of small intestinal transplantation in man.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suínos
/
Transplante Homólogo
/
Intestino Delgado
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Pediatr Surg
Ano de publicação:
1978
Tipo de documento:
Article