Analgesic effect of Dioclea grandiflora constituents in rodents.
J Ethnopharmacol
; 45(3): 207-10, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7623485
ABSTRACT
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Extratos Vegetais
/
Flavanonas
/
Analgésicos
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Brasil