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Evolution of protamine P1 genes in mammals.
Queralt, R; Adroer, R; Oliva, R; Winkfein, R J; Retief, J D; Dixon, G H.
Afiliação
  • Queralt R; Molecular Genetics Research Group, Faculty of Medicine, University of Barcelona, Spain.
J Mol Evol ; 40(6): 601-7, 1995 Jun.
Article em En | MEDLINE | ID: mdl-7643410
Protamine P1 genes have been sequenced following PCR amplification from 11 mammals representing five major mammalian orders: Rodentia (rat and guinea pig), Carnivora (cat and bear), Proboscidea (elephant), Perissodactyla (horse), and Artiodactyla (camel, deer, elk, moose, and gazelle). The predicted amino acid sequence for these genes together with previously reported sequences results in a data set of 25 different P1 genes and 30 different P1 amino acid sequences. The alignment of all these sequences reveals that protamines are amongst the most rapidly diverging proteins studied. In spite of the large number of differences there are conserved motifs that are also common to birds such as the N-terminal ARYR followed by the triple alternating SRSRSR phosphorylation site. The central region contains 3 arginine clusters consisting of 5-6 arginines each. The C-terminus appears to be the most variable region of the protamines. Overall the molecular evolution of P1 genes is in agreement with the expected species evolution supporting that these genes have evolved vertically.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protaminas / Evolução Biológica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Mol Evol Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Espanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protaminas / Evolução Biológica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Mol Evol Ano de publicação: 1995 Tipo de documento: Article País de afiliação: Espanha
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