Decreased muscarinic receptor binding in the arcuate nucleus in sudden infant death syndrome.
Science
; 269(5229): 1446-50, 1995 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-7660131
ABSTRACT
Muscarinic cholinergic activity in the human arcuate nucleus at the ventral medullary surface is postulated to be involved in cardiopulmonary control. A significant decrease in [3H]quinuclidinyl benzilate binding to muscarinic receptors in the arcuate nucleus is now shown to occur in sudden infant death syndrome (SIDS) infants, compared to infants dying acutely of known causes. In infants with chronic oxygenation abnormalities, binding is low in other nuclei, as well as in the arcuate nucleus. The binding deficit in the arcuate nucleus of SIDS infants might contribute to a failure of responses to cardiopulmonary challenges during sleep.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
/
7_ODS3_muertes_prevenibles_nacidos_ninos
Problema de saúde:
2_muertes_prevenibles
/
7_non_communicable_diseases
Assunto principal:
Quinuclidinil Benzilato
/
Morte Súbita do Lactente
/
Núcleo Arqueado do Hipotálamo
/
Receptores Muscarínicos
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Science
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos