DAU 6215, a novel 5-HT3-receptor antagonist, selectively antagonizes scopolamine-induced deficit in a passive-avoidance task, but not scopolamine-induced hypermotility in rats.
J Pharm Pharmacol
; 45(9): 841-3, 1993 Sep.
Article
em En
| MEDLINE
| ID: mdl-7903377
ABSTRACT
This study examined the effects of DAU 6215, a selective 5-HT3-receptor antagonist, on either impairment of a passive-avoidance task or hypermotility, both caused by scopolamine in rats. In the first experiment, scopolamine (0.75 mg kg-1, i.p.) disrupted acquisition of a one-trial 'step through' passive-avoidance response. Pretreatment with DAU 6215 (1, 10, 30 and 100 micrograms kg-1, i.p.) antagonized this deficit induced by scopolamine, with a bell-shaped dose-response curve. Scopolamine (0.75 mg kg-1, i.p.) produced a significant increase in locomotor activity which was unaffected by pretreatment with DAU 6215 (10 and 30 micrograms kg-1, i.p.). The present results further support the suggestion that 5-HT3-receptor antagonists may prevent the memory disturbance caused by a reduction in central cholinergic function in the rat. The inefficacy shown by DAU 6215 on hyperactivity induced by scopolamine appears to rule out the possibility of a pharmacokinetic interference between DAU 6215 and scopolamine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escopolamina
/
Antagonistas da Serotonina
/
Aprendizagem da Esquiva
/
Benzimidazóis
/
Compostos Bicíclicos com Pontes
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1993
Tipo de documento:
Article