HA-1A in septic patients with ARDS: results from the pivotal trial.
Intensive Care Med
; 20(5): 328-34, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-7930026
ABSTRACT
OBJECTIVE:
To evaluate the effects of HA-1A, a human monoclonal antiendotoxin antibody, in septic patients with ARDS.DESIGN:
Substudy of a multicenter, double-blinded, placebo-controlled trial of HA-1A in septic patients. PATIENTS 63 septic patients with ARDS at the time of study entry. INTERVENTION A single intravenous injection of HA-1A (100 mg) or placebo.RESULTS:
A quantitative radiographic score, the PaO2/FIO2 ratio and an index of the severity of ARDS did not show a significant difference between the treatment and placebo groups at 3, 5 and 7 days after treatment. The duration of endotracheal intubation did not differ between the two groups. 15 of 30 HA-1A treated patients (50%) and 23 of 33 placebo-treated patients (69.7%) died within 28 days. The daily mortality was always lower in the HA-1A group, but this difference was not statistically significant at 28 days. The 28-day survival curves for the two treatment groups adjusted by covariate analysis were not significantly different (p = 0.07). Using logistic regression, a significant independent effect of HA-1A treatment was detected upon the early survival rate at 7 days (p = 0.03) but not at 14 and 28 days.CONCLUSION:
A single injection of HA-1A in septic patients with ARDS did not reverse acute respiratory failure or improve long-term survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
4_TD
/
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
4_sepsis
/
6_other_respiratory_diseases
Assunto principal:
Síndrome do Desconforto Respiratório
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Imunoglobulina M
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Sepse
/
Endotoxinas
/
Anticorpos Monoclonais
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
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Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Intensive Care Med
Ano de publicação:
1994
Tipo de documento:
Article