Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task.
Pharmacol Biochem Behav
; 47(1): 95-9, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8115433
ABSTRACT
The effects of different doses (1, 10, 30, and 100 micrograms/kg, IP) of a new 5-hydroxytryptamine3 (5-HT3) receptor antagonist, 3-alpha-tropanyl)1H-benzimidazolone-3-carboxamide chloride (DAU 6215), on memory and performance deficits induced by SC 0.2 mg/kg scopolamine were assessed in the Morris water maze task. No effect was observed on the performance of rats treated with DAU 6215 alone. The doses of 10 and 30 micrograms/kg DAU 6215 attenuated these scopolamine-induced behavioral deficits.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Escopolamina
/
Antagonistas da Serotonina
/
Percepção Espacial
/
Benzimidazóis
/
Compostos Bicíclicos com Pontes
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Amnésia
/
Aprendizagem
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1994
Tipo de documento:
Article