Impact of stress on serum gastrin in Zollinger-Ellison syndrome.
Am J Gastroenterol
; 88(9): 1432-5, 1993 Sep.
Article
em En
| MEDLINE
| ID: mdl-8362843
ABSTRACT
We report an impressive case with Zollinger-Ellison syndrome (ZES), in which stress-induced sympathetic discharge influenced serum gastrin. Our patient was a 35-yr-old female who complained of frequent and massive vomiting (more than 4000 ml of gastric juice) which was aggravated especially by psychosocial stress. Basal hypergastrinemia (1900 pg/ml) was found after the admission. The most striking finding was that laboratory stress dramatically increased serum gastrin (from 1900 to 5400 pg/ml) and plasma noradrenaline (from 180 to 1130 pg/ml). Mental arithmetic stress further enhanced hypergastrinemia (5800 pg/ml) with a concomitant increase in plasma noradrenaline (1240 pg/ml). Neostigmine (10 micrograms/kg im) also increased serum gastrin up to 6100 pg/ml but propranolol (40 micrograms/kg i.v.) reduced these elevations (noradrenaline 990 pg/ml, gastrin 5000 pg/ml). In this case, the effect of stress on serum gastrin mimicked the effect of catecholamine infusion in ZES. These findings suggest that psychological stress induces serum gastrin secretion via beta-adrenoceptor with exacerbation of symptoms in some cases with ZES.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
Gastrinas
/
Síndrome de Zollinger-Ellison
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Am J Gastroenterol
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão