Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.
J Lipid Mediat
; 6(1-3): 249-57, 1993.
Article
em En
| MEDLINE
| ID: mdl-8395247
ABSTRACT
Structure and activity relationships of (methoxyalkyl)thiazole and 4-methoxytetrahydropyran series of 5-lipoxygenase inhibitors are reviewed. One member of the 4-methoxytetrahydropyran series, 6-([fluoro-5-(4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl)phenoxy]methyl) -1- methylquinol-2-one (ICI D2138), is undergoing clinical evaluation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Inibidores de Lipoxigenase
/
Quinolonas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Lipid Mediat
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Reino Unido