Lewis X antigen immunostaining in the diagnosis of transitional cell carcinoma.
Mod Pathol
; 8(6): 587-90, 1995 Aug.
Article
em En
| MEDLINE
| ID: mdl-8532688
ABSTRACT
Immunodetection of the Lewis X antigen has been suggested as a useful adjunct in the diagnosis of transitional cell carcinoma. To determine the specificity of Lewis X antigen immunostaining in this setting, we studied routinely processed, formalin-fixed tissue from 38 transitional cell carcinomas and 42 nonneoplastic urothelial lesions using the P12 monoclonal antibody to Lewis X antigen and an avidin-biotin immunohistochemical technique. Because Lewis X immunostaining of occasional umbrella cells has previously been noted in normal urothelium, staining of umbrella cells was not considered sufficient for a positive reaction in our study. Immunoreactivity for Lewis X antigen was seen in 34 of 38 (89%) cases of transitional cell carcinoma, in three of three cases of urothelial dysplasia, and in 20 of 39 (51%) of the reactive urothelial lesions. We conclude that immunostaining for the Lewis X antigen is not specific in the diagnosis of transitional cell carcinoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Carcinoma de Células de Transição
/
Biomarcadores Tumorais
/
Antígenos CD15
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Humans
Idioma:
En
Revista:
Mod Pathol
Assunto da revista:
PATOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos