Different effects of three high-dose oral calcium salts on acid-base metabolism, plasma electrolytes and urine parameters of rats.
Methods Find Exp Clin Pharmacol
; 17(7): 437-42, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-8577204
ABSTRACT
The oral calcium (Ca) load test has been applied to estimate the enteral absorbability of Ca salts in humans; provided that the deep bone compartments are filled up, excess Ca should be excreted in the urine. Using this "overflow model" three Ca salts were tested in rats at increasing oral doses of 0 to 14 mmol/kg body weight CaCO3 and two other compounds containing chloride at a CaCl ratio of 12 (CaCl2) and 11 (Ca-aspartate-hydrochloride). The carbonate was poorly absorbed and hence did not significantly affect acid-base metabolism nor urine pH. Both chloride-containing salts increased Ca excretion to a significantly higher degree in a dose-dependent manner; in contrast to the organic compound, the CaCl2 induced metabolic acidosis at 14 mmol/kg body weight. At decreasing base excess and urinary pH, renal excretion of Ca and of magnesium (Mg) increased, indicating that acid-base alterations must be considered when evaluating the oral load test. All Ca salts induced moderate hypomagnesemia pointing to decreased enteral absorbability of food-borne Mg in rats. Studies on volunteers reported in the literature suggest, however, that this effect is not relevant for humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbonato de Cálcio
/
Cloreto de Cálcio
/
Ácido Aspártico
/
Eletrólitos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha