A peptide sequence from platelet factor 4 (CT-112) is effective in the treatment of type II collagen induced arthritis in mice.
J Rheumatol
; 24(5): 890-8, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9150077
ABSTRACT
OBJECTIVE:
Platelet factor 4 (PF-4) is a critical alpha chemokine in inflammation and injury responses, with multiple effects upon cellular activities. Discrete peptide sequences of the PF-4 molecule have been shown to retain biological activity. Our aim was to examine the influence of the PF-4 derived octapeptide (CT-112; TTSQVRPR) on type II collagen induced arthritis in mice, to determine if this peptide exhibited antiinflammatory properties.METHODS:
DBA/1 mice were treated with CT-112 from either the time of immunization with type II collagen or from the initial onset of arthritis.RESULTS:
CT-112 both prevented the development of arthritis in mice treated prophylactically and reduced progression of disease in animals treated therapeutically, and was active when delivered by either subcutaneous injection or oral gavage. No marked immunosuppressive effects were observed during CT-112 treatment, with only moderate decrease in antibody levels and mitogen responses. A significant reduction of the circulating levels of IL-1 was a consistent finding in mice treated therapeutically with CT-112.CONCLUSION:
These data suggest PF-4 derived octapeptide exerts antiinflammatory effects of experimental arthritis in mice.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Fator Plaquetário 4
/
Colágeno
/
Artrite Reativa
/
Tiazolidinedionas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Rheumatol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos