Abnormal expression of serotonin transporter mRNA in the frontal and temporal cortex of schizophrenics.
Mol Psychiatry
; 2(1): 57-64, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-9154218
ABSTRACT
Postmortem brain tissue was used to measure expression of serotonin transporter mRNA in the left frontal and left temporal cortex from schizophrenics (n = 24) and from normal control individuals with no history of psychiatric illness (n = 10). There was an approximately four-fold increase of serotonin transporter mRNA in Brodmann's area 9 and a two-fold decrease in Brodmann's areas 21 and 22. The changes in serotonin transporter mRNA were more prominent in schizophrenics who had received neuroleptic drugs within 1 week prior to death than in schizophrenics who were neuroleptic-free for more than 2 weeks prior to death, suggesting that the changes may be related to neuroleptic treatment. There was no correlation between serotonin transporter mRNA levels and the sex or age of schizophrenic and control cases or the postmortem delay intervals. These results support the hypothesis that region-specific changes in serotonin transporter expression occur in brains of some schizophrenics. Future studies are necessary to determine whether the changes in serotonin transporter expression are drug-related or are associated with the illness itself.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_mental_health_behavioral_disorders
Assunto principal:
Proteínas de Membrana Transportadoras
/
Esquizofrenia
/
Lobo Temporal
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Lobo Frontal
/
Proteínas do Tecido Nervoso
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mol Psychiatry
Assunto da revista:
BIOLOGIA MOLECULAR
/
PSIQUIATRIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos