Free radicals, atherosclerosis, ageing and related dysmetabolic pathologies: biochemical and molecular aspects.
Eur J Cancer Prev
; 6 Suppl 1: S25-30, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9167135
ABSTRACT
In human ageing and with many pathologies correlated to the senile functional decay of cells, membrane damage often occurs in some organ or tissue, which provokes lipid peroxidation in the membrane and accelerates the disorder in structure and function of the membrane. When lipid peroxides accumulate sufficiently, they leak from the organ or tissue into the bloodstream and increase the lipid peroxide level in blood lipoproteins. The increased lipid peroxides in the blood attack the blood vessel and promote atherogenesis. This paper describes the possible involvement of free radicals in this damage, both to tissues and to blood vessels, which contributes to the senile functional decay of the tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arteriosclerose
/
Vasos Sanguíneos
/
Envelhecimento
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Eur J Cancer Prev
Assunto da revista:
NEOPLASIAS
/
SAUDE PUBLICA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Itália