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Expression of transforming growth factor beta in radiation interstitial pneumonitis.
Bai, Y H; Wang, D W; Cui, X M; Long, J Y; Cui, C B; Jia, C Y; Song, L W.
Afiliação
  • Bai YH; Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, P.R. China.
J Environ Pathol Toxicol Oncol ; 16(1): 15-20, 1997.
Article em En | MEDLINE | ID: mdl-9256927
We investigated the changes in transforming growth factor beta 1 (TGF-beta 1) mRNA and TGF-beta 3 protein expression that occur in radiation interstitial pneumonitis. We used TGF-beta 1-cDNA probe in situ hybridization and TGF-beta 3 polyclonal antibody in immunohistochemical techniques. Our results showed that the distribution of TGF-beta 1 mRNA and TGF-beta 3 protein basically coincided in blood vessels, airways, lung parenchyma, and alveolar macrophages. However, bronchial epithelial cells expressed only TGF-beta 3 proteins and no TGF-beta 1 mRNA. We found an increased expression of TGF-beta 1 mRNA and TGF-beta 3 proteins in radiation interstitial pneumonitis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Experimentais por Radiação / Fator de Crescimento Transformador beta / Pneumonite por Radiação Limite: Animals Idioma: En Revista: J Environ Pathol Toxicol Oncol Assunto da revista: NEOPLASIAS / PATOLOGIA / SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 1997 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Experimentais por Radiação / Fator de Crescimento Transformador beta / Pneumonite por Radiação Limite: Animals Idioma: En Revista: J Environ Pathol Toxicol Oncol Assunto da revista: NEOPLASIAS / PATOLOGIA / SAUDE AMBIENTAL / TOXICOLOGIA Ano de publicação: 1997 Tipo de documento: Article
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