Expression of transforming growth factor beta in radiation interstitial pneumonitis.
J Environ Pathol Toxicol Oncol
; 16(1): 15-20, 1997.
Article
em En
| MEDLINE
| ID: mdl-9256927
We investigated the changes in transforming growth factor beta 1 (TGF-beta 1) mRNA and TGF-beta 3 protein expression that occur in radiation interstitial pneumonitis. We used TGF-beta 1-cDNA probe in situ hybridization and TGF-beta 3 polyclonal antibody in immunohistochemical techniques. Our results showed that the distribution of TGF-beta 1 mRNA and TGF-beta 3 protein basically coincided in blood vessels, airways, lung parenchyma, and alveolar macrophages. However, bronchial epithelial cells expressed only TGF-beta 3 proteins and no TGF-beta 1 mRNA. We found an increased expression of TGF-beta 1 mRNA and TGF-beta 3 proteins in radiation interstitial pneumonitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões Experimentais por Radiação
/
Fator de Crescimento Transformador beta
/
Pneumonite por Radiação
Limite:
Animals
Idioma:
En
Revista:
J Environ Pathol Toxicol Oncol
Assunto da revista:
NEOPLASIAS
/
PATOLOGIA
/
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article