Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats.
Neurosci Lett
; 230(2): 129-32, 1997 Jul 18.
Article
em En
| MEDLINE
| ID: mdl-9259481
ABSTRACT
Kainic acid-induced limbic seizures cause lasting increases in neuropeptide Y (NPY) expression in hippocampal granule cells/mossy fibers. The expression of NPY-Y1 receptors in these neurons were investigated, using in situ hybridization for Y1 mRNA and receptor autoradiography with the Y1-specific ligand [125I][Pro34]PYY. Six hours after kainic acid-induced seizures, Y1 receptor mRNA levels decreased by 80% in granule cells and concomitantly increased (by 75%) in CA2 pyramidal neurons. Subsequently, persistent decreases in Y1 mRNA were seen, both in the stratum granulosum and in CA2. Changes in mRNA concentrations were accompanied by a transient, although non-significant, increase in [125I][Pro34]PYY binding in the molecular layer of the dentate gyrus after 4-6 h which was succeeded by a lasting decrease in binding which indicates a persistent down-regulation of Y1 receptors in hippocampal areas in kainic acid-induced epilepsy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Receptores de Neuropeptídeo Y
/
Células Piramidais
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Epilepsia
/
Hipocampo
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Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Áustria